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BPC-157 and KPV are two peptides that have attracted attention in the fields of regenerative medicine and gastrointestinal research due to their complementary mechanisms of action. While BPC-157 is known for its potent tissue repair properties, KPV has emerged as a selective antagonist of the gut peptide receptor that can mitigate inflammatory signaling pathways. When combined with N-Acetyl Larazotide, these peptides form a synergistic formula aimed at treating chronic gastrointestinal inflammation, such as that seen in Crohn’s disease, ulcerative colitis and leaky gut syndrome.



Gastro Inflammation Research Formula (BPC-157, KPV, N-Acetyl Larazotide)



The Gastro Inflammation Research Formula is a research-grade blend of three active peptides. The base component is BPC-157, a stable pentadecapeptide derived from body protein that promotes angiogenesis and fibroblast migration. Its primary effect is to accelerate the healing of damaged tissues in the gut wall by increasing vascular supply and modulating growth factor release.



KPV, a tripeptide consisting of lysine, proline and valine, acts as an antagonist for the Mas-related G-protein coupled receptor (MRGPR). By blocking this receptor on intestinal epithelial cells, KPV dampens the downstream inflammatory cascade that is often triggered by bacterial lipopolysaccharides or cytokines. This results in a reduction of mucosal permeability and a decrease in neutrophil infiltration.



N-Acetyl Larazotide is a tight junction stabilizer. It binds to zonulin receptors on enterocytes, preventing the conformational change that leads to paracellular leakiness. When used together with BPC-157 and KPV, N-Acetyl Larazotide reinforces barrier integrity while the other two peptides repair and protect the underlying tissue.



Product Description



The product is supplied as a sterile, 5 mg vial of each peptide in a lyophilized powder form, ready for reconstitution. The formula is designed for intravenous or subcutaneous administration, with a recommended dosage schedule that can be adjusted by researchers based on experimental protocols. Each vial contains a high purity grade (≥98 %) suitable for animal studies and preclinical investigations.



The packaging is sealed under nitrogen to preserve peptide stability, and the product comes with detailed instructions for reconstitution using bacteriostatic water or sterile saline. A full safety data sheet accompanies the shipment, outlining handling precautions and storage conditions at 2–8 °C in a protected environment.



Peptide Specifications



BPC-157




Molecular formula: C66H108N16O20


Mass: 1 640 Da


Isomeric purity: >98 %


Solubility: 10 mg/mL in sterile water for injection


Stability: Stable at 2–8 °C for up to 12 months; freeze-thaw cycles should be minimized



KPV


Molecular formula: C12H21N3O4


Mass: 239 Da


Isomeric purity: >99 %


Solubility: 50 mg/mL in sterile saline


Stability: Stable at room temperature for up to 6 months; refrigeration recommended for extended storage



N-Acetyl Larazotide


Molecular formula: C26H41NO12


Mass: 599 Da


Isomeric purity: >97 %


Solubility: 5 mg/mL in sterile water


Stability: Stable at 2–8 °C for up to 18 months; protect from light



All peptides are synthesized using solid-phase peptide synthesis techniques and purified by reverse-phase high performance liquid chromatography. The final product is verified by mass spectrometry and analytical HPLC, ensuring batch-to-batch consistency.

The Gastro Inflammation Research Formula thus provides a comprehensive toolkit for researchers investigating the molecular underpinnings of gut inflammation and testing therapeutic interventions aimed at restoring mucosal integrity while modulating inflammatory signaling pathways.